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* Medical Insight, Inc 2022. Cosmetic Neurotoxin Market Study. January 2022. Based on worldwide neurotoxins 2021 (in sales value). 1 BOTOX® Prescribing Information. HK-41906. May 2013. 2 De Boulle K, et al. Dermatol Surg. 2018;44(11):1437–1448. 3 Trindade de Almeida A et al. Dermatol Surg 2015; 41: S19-S28. 4 Yu W et al. J Cosmet Laser Ther. 2018Oct;20(5):278-286. 5 Lowe NJ et al. J Am Acad Dermatol. 2007;56(4):604-611. 6 He J, Wang T and Dong J. Journal of Dermatological Treatment. 2012; 23: 461–464. 7 U.S. Food and Drug Administration, Department of Health & Human Services. Botox approval letter 85-0226 & 85-0227, December 29, 1989. 8 Allergan. Unpublished Data. REF-100250. BOTOX® number of peer-reviewed articles vs competitors. August 2022.